A dedicated paediatric [18F]FDG PET/CT dosage regimen

Abstract Background The role of 2-[ 18 F]fluoro-2-deoxy-D-glucose ([ F]FDG) positron emission tomography/computed tomography (PET/CT) in children is still expanding. Dedicated paediatric dosage regimens are needed to keep the radiation dose as low reasonably achievable and reduce risk radiation-induced carcinogenesis. aim this study investigate relation between patient-dependent parameters [ F]FDG PET image quality order propose a dedicated regimen. Methods In retrospective analysis, 102 85 adults were included that underwent diagnostic PET/CT scan. scans was measured by signal-to-noise ratio (SNR) liver. SNR liver normalized (SNRnorm) for administered activity acquisition time apply curve fitting with body weight, length, mass index, weight/body length surface area. Curve performed two power fits, nonlinear two-parameter model α p −d linear single-parameter −0.5 . fit preferred combined user obtain at least moderate or good regimen proposal. Results Body weight demonstrated highest coefficient determination (R 2 = 0.81) 0.80) models. Akaike’s corrected information criterion. We decided use 6.5, based on expert opinion three nuclear medicine physicians. Comparison quadratic adult protocol confirmed need different both patient groups. study, amount can be considerably reduced comparison current guidelines. Conclusion has strongest children. proposed will provide constant clinical sufficient significant reduction effective compared A necessary, universal dosing not feasible.